This came up as a question on Stack Overflow a while ago. While Python is noted for its use in many games, here’s a list of professional-quality games that use Pygame:
 Dangerous High School Girls in Trouble is a 2D RPG by Keith Nemitz that was nominated for a Writers Guild Award, won “Most Innovative Game” by the Casual Games Association, and was also selected as a finalist for the 2008 IndieCade Festival of Independent Games. It is available for purchase off of Steam. Gameplay video |
 Analogue: A Hate Story is a visual novel-style game that was a 2012 IndieCade Finalist. As of December 2012, Analogue has sold at 40,000 copies. Steam store link (with videos). |
 Unity of Command is a turn-based, operational-level wargame that covers the entire 1942/43 Stalingrad Campaign on the Eastern Front. Trailer video. Available on Steam. |
 Frets on Fire is an open source Guitar Hero clone. Gameplay video |
 7 Grand Steps is a board-like puzzle game from Keith Nemitz of Mousechief and is a 2013 Independent Games Festival finalist. Trailer video |
 Metin2 is an Oriental-themed action MMORPG. Trailer video |
 Galcon 2 is a high-paced space shooter game. Gameplay video |
 SolarWolf is an updated clone of the 1983 arcade shooter Solar Fox. It is included with several Linux distributions. Download links Gameplay video |
 División Especial de Detectives is an original puzzle game in Spanish that explores the culture and history of Uruguay. Gameplay video |
 The Witch’s Yarn is an interactive story game from Mousechief. Gameplay video |
While not a game, someone has mentioned that the Minecraft editor MCEdit used Pygame. MCEdit tutorial video
Feel free to add any other professional-quality games that have been made using Pygame in the comments section!
Don’t forget Unity of Command! This turned out to be one of the best wargames of the past few years.
http://unityofcommand.net/
Posted by Michael on February 19th, 2013.
What is an ‘oriental themed’ game?
Posted by Jim on February 19th, 2013.
@Jim Oriental refers to the far east ie. China, Japan, Korea.
Posted by Willrandship on February 20th, 2013.
Thanks for the suggestion Michael! I’ve added Unity of Command to the list. It looks like a great game.
Posted by Al Sweigart on February 21st, 2013.
My Ex-Boyfriend the Space Tyrant! is new and python
Posted by Luke on February 22nd, 2013.
If you like visual novel you can check these games:
http://www.sakevisual.com/jisei/
http://www.sakevisual.com/kansei/
http://www.sakevisual.com/yousei/
Posted by Luis on February 25th, 2013.